Science
A. the functional immune manifold
Context Matters in I&I
We probe responses in healthy and disease-associated backgrounds. Our discovery funnel combines fast functional imaging with deep molecular profiling.
Many Diseases, One Map
Some immune-mediated diseases share mechanisms, while others are unique. We probe mechanisms across multiple disease-relevant contexts at once.
Perturbation Screening to Ground AI
We learn about how disease works by pushing cell states with many parallel tool perturbations in the lab. AI predictions get grounded in real lab feedback.
Not Every Patient
Varied cell backgrounds are messy but necessary: therapies frequently don't work or have unacceptable side effects. Our platform can determine the difference in advance.
Guided Exploration
Each iteration guides the last, making a vast space of immune-relevant conditions accessible for the first time. Every validation round improves our predictions further.
The Functional Immune Manifold
Conditions, backgrounds, and cell context combine into a coherent picture of immune biology; with many downstream applications from positioning to development.
B. publications
Quantifying ex vivo model realism for novel target discovery in inflammatory diseases
Poster, Target Validation in the Era of Genomics, Big Data and AI, Hinxton,
Functional Profiling of Rheumatoid Arthritis Reveals Disease-Specific Immunomodulatory Responses and Novel Therapeutic Targets
Poster, IMMUNOLOGY2026, Boston,
Functionally-Guided Multiomics Profiling of Human Systemic Inflammation Identifies Myeloid Therapeutic Targets
Poster, Keystone Symposia, Autoimmunity and Autoinflammation,
Decoding the functional and molecular niche of immune-mediated disease for iterative target discovery
Poster, CytoData 2025, Berlin,
C. selected prior work
Graph owes a lot to our co-founders' pioneering research on imaging-based drug testing in primary human cells. Our decade-long work with these models, both in industry and academia, has taught us the rigor required to translate modeling insights into therapies and biomarkers that reach patients.
- Hale, Severin … Snijder. Cellular architecture shapes the naïve T cell response. Science, 2024.Found a novel primed T-cell morphology quantifiable by high throughput imaging
- Severin, Hale … Snijder. Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes. Science Advances, 2022.Multiplexed image-based quantification of immune subtypes and morphologies
- Shilts, Severin … Snijder, Wright. A physical wiring diagram for the human immune system. Nature, 2022.Collaboration linking image-based functional endpoints to physically measured surface protein interactions
- Vladimer, Snijder … Superti-Furga. Global survey of the immunomodulatory potential of common drugs. Nature Chemical Biology, 2017.Foundational image-based perturbation screen across 1400+ compounds